The development of capsule endoscopy (CE) and double balloon enteroscopy\n(DBE) has significantly enhanced the visualization of the small bowel. CE and\nDBE have proven to be the choice of investigation for the diagnosis of small\nbowel disease and is an evident indication for obscure gastrointestinal bleeding\n(OGIB). CE or DBE respectively are frequent option of professionals for\nthe diagnosis of obscure gastrointestinal bleeding. The purpose of this review\nis to provide an overview of studies focused on patients with obscure gastrointestinal\nbleeding with previous CE and/or DBE intervention. Studies\nshow that CE and DBE have similar diagnostic yields for obscure gastrointestinal\nbleeding. Although with few chances for false negative results, most researches\nshowed good concordance between CE and DBE. However due to its\nnon-invasiveness, safety, patient tolerability and ability to view the entire\nsmall bowel, CE can be recommended as a first choice of investigation. DBE,\ndespite being more invasive, is a necessary second choice, which has both\ndiagnostic and therapeutic value, although skilled endoscopist and sedation\nare required and complications like bleeding, perforation, pancreatitis etc.\nmay occur.
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